Human Health and Gut Phageome
Human Health and Microbiome
We need a stable, balanced gut microbiome (GM) to be healthy. Bacteriophages play an important role in maintaining healthy GM function. <Healthy Human Gut Phageome> by Manrique et al., published in PNSAS, investigated the relationship between human health and gut phageome, analyzed the healthy gut phageome (HGP) that healthy people have in common. This study proved that a healthy gut phageome contribute to maintaining human health.
Healthy Gut Phageome (HGP)
The study got bacteriophage dataset from 64 healthy people around the world and conducted rank abundance analysis and DNA sequence dataset analysis. As a result, they found shared bacteriophages in healthy individuals.
The analyzed bacteriophages can be divided into three classes: The core, the common, and the low overlap/unique bacteriophage. The core was found in more than one-half of all individuals, and the common was shared in 20~50% of individuals. We refer to both core and common bacteriophages as the “healthy gut phageome,” or HGP.
Taking the HGP ratio between healthy people and irritable bowel syndrome (IBD) patients, for example, about 62% of healthy people had core bacteriophages, while only 42% and 54% of ulcerative colitis and Crohn’s patients had core bacteriophages, respectively. These results support the contribution of HGP to maintaining health and suggest that HGP is significantly perturbed in diseased patients.
iNtRON Bio and Microbiome
iNtRON Bio is targeting the infectious diseases area based on our unique endolysin technology and developing new drugs (PHAGERUS & PHAGEOME) based on bacteriophage technology for the applications in the microbiome, brain diseases, and vaccine field. As a global leader in infectious disease using bacteriophage, iNtRON Bio has secured a phage platform technology and more than 500 useful phage libraries.
Using our platform technology and bacteriophage library, we are developing human gut system control and treatment, and we will continue to develop new drug candidates that can treat abnormal microbiome-related diseases such as Alzheimer’s, Crohn’s , and Parkinson’s disease.
It is iNtRON.
Healthy human gut phageome
Pilar Manrique, Benjamin Bolduc, Seth T. Walk, John van der Oost, Willem M. de Vos, Mark J. Young
Proceedings of the National Academy of Sciences Sep 2016, 113 (37) 10400-10405; DOI: 10.1073/pnas.1601060113